Immunohematology and Genomics

NYBC's Laboratories of Immunohematology and Blood Group Genomics provide two main services:

  1. Reference laboratory testing and consultation to assist in resolving patient antibody problems.
  2. Providing specialized blood products for transfusion.

The laboratories, under the direction of Connie Westhoff, SBB, PhD (cwesthoff@nybloodcenter.org), receive more than 2,000 requests annually from hospitals and blood centers nationwide for help in identifying antibodies, and ongoing requests for assistance in matching donors to patients. The Laboratory also actively screens samples to identify donors whose red blood cells lack a high prevalence antigen or have uncommon blood group combinations.

These laboratories combine state-of-the-art methods in serological investigation and DNA blood group analysis to resolve complex cases, determine clinical significance, and provide consultation for selection of blood for transfusion.

Ask us how we can:

  • Improve your blood typing accuracy
  • Optimize compatible donor selection
  • Aid the management and treatment of neonatal and fetal red cell or platelet destruction
  • Improve transfusion safety and outcomes for patients

Want more information?

We are known worldwide for expertise in resolving complex antibody investigations, with one of the most extensive collections of well-characterized red cells and antisera and one of the largest inventories of liquid and frozen donor units to support patients who need antigen-negative units for transfusion.

The laboratory, under the technical direction of Christine Lomas-Francis, MSc, FIBMS, and Helene DePalma, MT(ASCP) SBB, CQA (ASQ), Director of Operations and Quality, consists of a highly trained and experienced professional staff knowledgeable in immunohematology and genetics.

Immunohematology Testing Services

  • Improve your blood typing accuracy
  • Optimize compatible donor selection
  • Aid the management and treatment of neonatal and fetal red cell or platelet destruction
  • Improve transfusion safety and outcomes for patients
  • Resolution of complex red cell alloantibody problems
  • Hemolytic Anemia investigation
  • Warm and cold autoantibodies
  • Transfusion reaction investigation
  • Hemolytic disease of the fetus and newborn
  • Direct antiglobulin test
  • Antibody titrations (prenatal and cold agglutinin)
  • ABO and D discrepancy resolution
  • Adsorption and elution
  • Donath-Landsteiner test
  • Polyagglutination 
  • Extensive inventory of antigen-negative RBC products
  • RBC products typed for additional antigens such as CW, Jsa, Kpa, Lea, M, V, VS, Wra and DAK
  • High volume donor testing for RBC products in partnership with Genomics providing RBC products typed for Doa, Dob, hrB, hrS, HY, Joa, and U
  • Participate in the American Rare Donor Program (ARDP) to find rare blood that cannot be found locally

    Provision of RBC Products for Alloimmunized Patients

    New Program Initiative: NYBC Helps You Be Redi to Reduce Alloimmunization

    • Extensive inventory of antigen-negative RBC products
    • RBC products typed for additional antigens such as CW, Jsa, Kpa, Lea, M, V, VS, Wra and DAK
    • High volume donor testing for RBC products in partnership with Genomics providing RBC products typed for Doa, Dob, hrB, hrS, HY, Joa, and U
    • Participate in the American Rare Donor Program (ARDP) to find rare blood that cannot be found locally

    Helpful Resources

    Laboratory of Immunohematology and Genomics Brochure

    Quick Reference Guide

    Redi to Reduce Alloimmunization Brochure

    Bloodology I: An Introduction to Blood, Blood Donation, and Transfusion

    Bloodology II: Taking a Closer Look at Red Blood Cells and Blood Types

    Bloodology III: What Happens to Your Blood after You Donate? - Tracing the path of blood donations

    Forms

    Request for Serological Investigation Form

    Blood Group Systems Form

    Sample Submission Form