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Sickle Cell Disease - NYBCe Publications

Therapeutics

Liu Y, Zhong H, Bao W, Mendelson A, An X, Shi P, Chou ST, Manwani D, Yazdanbakhsh K. Patrolling monocytes scavenge endothelial adherent sickle RBC: a novel mechanism of inhibition of vaso-occlusion in SCD. Blood. 2019 Aug 15;134(7):579-590.  (Plenary paper and Cover issue)

Liu Y, Jing F, Yi F,  Mendelson A, Shi P, Walsh R, Friedman DF, Minniti C, Manwani D, Chou ST, and Yazdanbakhsh K.  HO-1hi Patrolling Monocytes Protect against Vaso-occlusion in Sickle Cell Disease. Blood 2018, Apr 5;131(14):1600-1610. (Commentary by Gordeuk VR. Blood. 2018 Apr 5;131(14):1503-1505). 

Boulad F, Shore T, van Besien K, Minniti C, Barbu-Stevanovic M, Fedus SW, Perna F, Greenberg J, Guarneri D, Nandi V, Mauguen A, Yazdanbakhsh K, Sadelain M, Shi PA. Safety and efficacy of plerixafor dose escalation for the mobilization of CD34+ hematopoietic progenitor cells in patients with sickle cell disease: interim results.Haematologica. 2018 May;103(5):770-777.

Louie JE, Anderson CJ, Fayaz M Fomani K, Henry A, Killeen T, Mohandas N, Yazdanbakhsh K, Belcher JD, Vercellotti GM, Shi PA.  Case series supporting heme detoxification via therapeutic plasma exchange in acute multiorgan failure syndrome resistant to red blood cell exchange in sickle cell disease.Transfusion. 2018 Feb;58(2):470-479

Vinchi F, Costa da Silva M, Ingoglia G, Petrillo S, Brinkman N, Zuercher A, Cerwenka A, Tolosano E and Muckenthaler M U. Hemopexin therapy reverts heme-induced pro-inflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.Blood. 2016;127(4):473-486.

Choi E, Branch C, Cui MH, Yazdanbakhsh K, Mohandas N, Billett HH, Shi PA.  No evidence for cell activation or brain vaso-occlusion with plerixafor mobilization in sickle cell mice.Blood Cells Mol Dis. 2016; 57:67-70.

Shi PA, Choi E, Chintagari NR, Nguyen J, Guo X, Yazdanbakhsh K, Mohandas N, Alayash A, Manci EA, Belcher JD, Vercellotti GM.  Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function.Br J Haematol. 2016 Nov;175(4):714-723

Manwani D, Chen G, Carullo V, Serban S, Olowokure O, Jang J, Huggins M, Cohen HW, Billett H, Atweh GF, Frenette PS, Shi PA.  Single-dose intravenous gammaglobulin can stabilize neutrophil Mac-1 activation in sickle cell pain crisis.  Am J Hematol. 2015 May;90(5):381-5.

Shi PA, Manwani D, Olowokure O, Nandi V. Serial Assessment of Laser Doppler Flow during Acute Pain Crises in Sickle Cell Disease.  Blood Cells Mol Dis 2014; 53(4):277-82.

Vinchi F, De Franceschi L, Ghigo A, Townes T, Cimino J, Silengo L, Hirsch E, Altruda F and Tolosano E. Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases.Circulation, 2013 Mar 26;127(12):1317-1329.

Antigen matching and immunological responses to transfusion

Chou ST, Evans P, Vege S, Coleman SL, Friedman DF, Keller M, Westhoff CM. RH genotype matching for transfusion support in sickle cell disease.Blood. 2018, 132:1198-1207. (Commentary by Hendrickson JE, Tormey CA.Blood. 2018 Sep 13;132(11):1091-1093).

Chou ST, Flanagan JM, Vege S, Luban NLC, Brown RC, Ware RE, Westhoff CM. Whole-exome sequencing for RH genotyping and alloimmunization risk in children with sickle cell anemia.  Blood Advances 2017,1: 1414-1422. 

Godefroy E, Liu Y, Shi P, Mitchell WB, Cohen D, Chou ST, Manwani D, Yazdanbakhsh K. Altered heme-mediated modulation of dendritic cell function in sickle cell alloimmunization.Haematologica. 2016, Sep;101(9):1028-38.

Casas J, Friedman D.F, Jackson T.,Vege S., Westhoff CM, Chou ST. Changing practice: red blood cell typing by molecular methods for patients with sickle cell disease. Transfusion 2015, 55:1388-93.

Godefroy E, Zhong H, Pham P, Friedman D, Yazdanbakhsh K. TIGIT+ Circulating Follicular Helper T cells Display Robust B cell Help Functions: Potential Role in Sickle Cell Alloimmunization.Haematologica. 2015, Nov;100(11):1415-25. (Commentary by Pirenne F. Haematologica. 2015 Nov;100(11):1371-3)

Zhong H, Bao, W, Freidman, D and Yazdanbakhsh K. Hemin controls T cell polarization in sickle cell alloimmunization. J Immunol. 2014 Jul 1;193(1):102-10. (Article highlighted in Hematologist 2014, 11(5))

Chou ST, Jackson T, Vege S, Smith-Whitley K, Friedman DF, Westhoff CM. High prevalence of red blood cell alloimmunization in sickle cell disease despite transfusion from Rh-matched minority donors.Blood, 2013, 122: 1062-1071. (Commentary byThompson AA. Blood. 2013 Aug 8;122(6):858-9.

Bao W, Zhong H, Manwani, D., Vasovic,L., Uehlinger, J., Lee MT, Sheth S, Shi, P., and Yazdanbakhsh K. Regulatory B cell Compartment in Transfused Alloimmunized and Non-alloimmunized Patients with Sickle Cell Disease.Am J Hematol. 2013 88(9):736-40.

Bao W, Zhong H, Li X, Lee MT, Schwartz J, Sheth S, Yazdanbakhsh K. Immune regulation in chronically transfused allo-antibody responder and nonresponder patients with sickle cell disease and β- thalassemia major. Am J Hematol. 2011 Dec;86(12):1001-6.

Infections

Yi W, Bao W, Rodriguez M, Liu Y, Singh M, Ramlall V, Cursino-Santos JR, Zhong H, Elton CM, Wright GJ, Mendelson A, An X, Lobo CA, Yazdanbakhsh K. Robust adaptive immune response against Babesia microti infection marked by low parasitemia in a murine model of sickle cell disease.Blood Adv. 2018 Dec 11;2(23):3462-3478. (Cover issue)

Cursino-Santos JR, Singh M, Senaldi E, Manwani D, Yazdanbakhsh K, Lobo CA. Altered parasite life-cycle processes characterize Babesia divergens infection in human sickle cell anemia.Haematologica. 2019 Mar 28. pii: haematol.2018.214304. 

Minority Blood donations

Frye V, Caltabiano M, Kessler D, Schaffler H, Reboza M, Hillyer C, Shaz B. Evaluating a program to increase blood donation among racial and ethnic minority communities in New York City. Transfusion 2014;54:3061-7.

Shaz BH, James AB, Hillyer KL, Schreiber G, Hillyer CD. Demographic patterns of blood donors and donations in a large metropolitan area. Journal of National Medical Association 2011;103:351-7.

James AB, Demmons DG, Schreiber GB, Hillyer CD, Shaz BH. Contribution of attitudinal factors to blood donation in African American church attendees. Transfusion 2011;51:158-65.

Shaz BH, Demmons DG, Crittenden CP, Carnevale CV, Lee M, Burnett M, Easley K, Hillyer CD. Motivators and barriers to blood donation in African American college students. Transfusion and Apheresis Science 2009;41:191-7.

Reviews

Shi PA, Yazdanbakhsh K. Transfusion in Sickle Cell Disease: Current Practice and Understanding of its Utility.ISBT Sci Ser. 2020.

Liu Y, Zhong H, Vinchi F, Mendelson A, Yazdanbakhsh K. Patrolling monocytes in sickle cell hemolytic conditions. Transfus Clin Biol. 2019 Feb 22. pii: S1246-7820(19)30032-1. 

Pirenne, F., Yazdanbakhsh K. How I safely transfuse patients with sickle cell disease and manage delayed hemolytic transfusion reactions.Blood. 2018, Jun 21;131(25):2773-2781.

Zhong H, and Yazdanbakhsh K. Hemolysis and immune regulation.Curr Opin Hematol. 2018 May;25(3):177-182.

Yazdanbakhsh K. Immunoregulatory networks in sickle cell alloimmunization.Hematology Am  Soc Hematol Educ Program. 2016 Dec 2;2016(1):457-461.

Chou ST, Westhoff CM. Application of genomics for transfusion therapy in sickle cell anemia.Blood Cells Mol Dis. 2017, 67:148-154.  PMID: 28827079

Yazdanbakhsh K, Shaz, BH, Hillyer, CD. Immune regulation of sickle cell alloimmunization.ISBT Sci Ser. 2017 Feb;12(1):248-253.

Vinchi F and Tolosano E. Therapeutic Approaches to Limit Hemolysis-Driven Endothelial Dysfunction: Scavenging Free Heme to Preserve Vasculature Homeostasis. Oxidative Medicine and Cellular Longevity, 2013;2013:396527.

Yazdanbakhsh K., Ware, R and Noizat-Pirenne, F. Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management.Blood. 2012;120(3):528-37.

Shaz BH, Hillyer CD. Minority donation: challenging and needs. Current Opinion in Hematology 2010;17:544-9.