Patricia Shi, MD

Shi, Patricia-cropped.jpg

Medical Director
Head, Clinical Research in Sickle Cell Disease
Assistant Member, Lindsley F. Kimball Research Institute

Research Area

Our team is interested in translational research in sickle cell disease, with the goal of helping to develop new therapies for sickle cell disease.  We initiated and completed a phase I trial of intravenous gammaglobulin for pain crisis, and we are currently studying the utility of haptoglobin and/or hemopexin replacement therapy.   We are also interested in studying cellular therapy aspects of sickle cell disease, such as plerixafor mobilization of hematopoietic stem cells for gene therapy and autologous cord blood characteristics.

Contact Information

Phone: +1 (212) 570-3046

Funding Support

  • Doris Duke Charitable Foundation Innovations in Clinical Research Award Sadelain/Shi (Co-PIs) 1/2012-12/2017(NCE) “Preclinical evaluation of globin gene transfer in mobilized sickle cell disease patient CD34+ cells”
  • ​Doris Duke Charitable Foundation Collaborations in Sickle Cell Disease Research​Shi/ Sadelain/Chi (Co-PIs) 11/2016-10/2017 ​“Comparison between cord blood and adult hematopoietic progenitor cells from people with sickle cell disease of characteristics predicting superior gene therapy efficacy”​​
  • Rose M. Badgeley Residuary Charitable Trust PI: Shi  07/2017 -07/2018 "Therapeutic plasma exchange for complications of sickle cell disease”

Education and Training

Doctoral Training
M.D.  Duke University
Fellowship in Hematology:  Hematology Branch, NHLBI, NIH
Fellowship in Transfusion Medicine:  Johns Hopkins