Lindsley F. Kimball Research Institute (LFKRI) is the research branch of New York Blood Center. Since its establishment in 1964, LFKRI's research efforts have paved the way for new blood-related products, techniques and therapies. The Institute's commitment to ground-breaking research has resulted in numerous landmark patents and licenses.
- Pathogen Inactivation Technology: Created a solvent detergent procedure to inactivate viruses in blood plasma, thereby reducing the risk of hepatitis and HIV transmission through plasma transfusions.
- Cellular Therapy: Demonstrated the feasibility of using cord blood stem cells for transplantation as a treatment option for a number of human diseases.
- HIV Epidemiology: Detailed epidemiological studies on the prevalence of HIV infection in New York City.
- Viral Screening and Vaccine Development: Identified the hepatitis C virus and developed a practical screening method for hepatitis B as well as a safe, effective and affordable vaccine.
- Blood Group Genomics: Molecularly characterized a number of clinically relevant red cell blood group antigens and established donor-recipient genotype matching approach for transfusion.
- Meet Our Investigators
LFKRI Continues at the Forefront of Blood Disease Research
As one of the preeminent research institutes devoted to blood disease research, LFKRI’s pioneering investigators have a remarkable depth of experience and expertise in their fields and their research programs are supported with funding from federal, state and industrial sources.
To learn more about our Areas of Research click on the titles below:
- Transfusion Medicine
Developing new molecular approaches and tools to advance safer transfusions
- Beth Shaz - Clinical and Translational Transfusion Medicine-hemovigilance, transfusion management and next generation blood products
- Eric Senaldi - Clinical Transfusion-apheresis and platelet transfusions
- Connie Westhoff - Immunohematology and Genomics-blood group biology and novel diagnostic products
- Karina Yazdanbakhsh - Transfusion Immunology and Platelet Autoimmunity-alloimmunization , immune cytopenias
Elucidating molecular and cellular basis of hematological disorders
- Mohandas Narla - Experimental Hematology-red blood cell physiology and production
- Xiuli An - Molecular Hematology-erythropoiesis and red cell disorders
- Bruce Sachais - Translational Hematology-Pathobiology of platelets and platelet molecules
- Patricia Shi - Clinical Hematology- gene therapy and novel therapeutics for Sickle Cell Disease
- Infectious Disease
Discovering new vaccines and prevention strategies against infectious diseases
- Asim Debnath - Molecular Modeling and Drug Design-small molecule HIV inhibitors
- Shibo Jiang - Viral Immunology- anti-viral therapeutic agents: HIV, influenza, MERS, SARS
- Lanying Du - Experimental Virology-Coronavirus and Zika diagnostics and prevention
- Cheryl Lobo - Experimental Parasitology-host-parasite interactions: Malaria and Babesia
- Sara Lustigman - Parasite Biology and Vaccinology-River Blindness and Elephantitis
- Hong van Tieu - Clinical Epidemiology-HIV vaccine and therapeutic trials
- Debbie Kessler - Transfusion Epidemiology-Blood safety surveillance
- Vijay Nandi - Statistical and Data Analysis
- Cell Therapy
Defining the utility of stem cells in transplantation and regenerative medicine
- Rona Weinberg - Immunotherapeutics-cell product manufacturing
- Pablo Rubinstein - Cord Blood banking and Transplantation- hematopoietic cord blood banking and transplantation
- Andromachi Scaradavou - Clinical Transplantation-hematopoietic cord blood cells